Serveur d'exploration SRAS

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Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Identifieur interne : 001678 ( Main/Exploration ); précédent : 001677; suivant : 001679

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Auteurs : Marta L. Dediego [Espagne] ; Jose L. Nieto-Torres [Espagne] ; Jose M. Jimenez-Guarde O [Espagne] ; Jose A. Regla-Nava [Espagne] ; Carlos Casta O-Rodriguez [Espagne] ; Raul Fernandez-Delgado [Espagne] ; Fernando Usera [Espagne] ; Luis Enjuanes [Espagne]

Source :

RBID : PMC:4261026

Descripteurs français

English descriptors

Abstract

Highlights

Coronaviruses have evolved proteins to counteract innate immune responses.

Several diseases induced by coronaviruses have an immunopathological origin.

SARS-CoV E protein is essential to induce an inflammatory response leading to death.

E protein amino-terminal, transmembrane and carboxy-terminal domains foster virulence.

E protein ion channel activity and PDZ domain binding motif promote edema, ARDS and disease.


Url:
DOI: 10.1016/j.virusres.2014.07.024
PubMed: 25093995
PubMed Central: 4261026


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<term>Virulence Factors (metabolism)</term>
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<term>Facteurs de virulence (génétique)</term>
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<term>Immunité innée</term>
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<term>Virulence Factors</term>
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<term>Protéines de l'enveloppe virale</term>
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<title>Highlights</title>
<p>
<list list-type="simple" id="lis0005">
<list-item id="lsti0005">
<label></label>
<p id="par0005">Coronaviruses have evolved proteins to counteract innate immune responses.</p>
</list-item>
<list-item id="lsti0010">
<label></label>
<p id="par0010">Several diseases induced by coronaviruses have an immunopathological origin.</p>
</list-item>
<list-item id="lsti0015">
<label></label>
<p id="par0015">SARS-CoV E protein is essential to induce an inflammatory response leading to death.</p>
</list-item>
<list-item id="lsti0020">
<label></label>
<p id="par0020">E protein amino-terminal, transmembrane and carboxy-terminal domains foster virulence.</p>
</list-item>
<list-item id="lsti0025">
<label></label>
<p id="par0025">E protein ion channel activity and PDZ domain binding motif promote edema, ARDS and disease.</p>
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<name sortKey="Kuri, T" uniqKey="Kuri T">T. Kuri</name>
</author>
<author>
<name sortKey="Blakqori, G" uniqKey="Blakqori G">G. Blakqori</name>
</author>
<author>
<name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name>
</author>
<author>
<name sortKey="Ludewig, B" uniqKey="Ludewig B">B. Ludewig</name>
</author>
<author>
<name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations>
<list>
<country>
<li>Espagne</li>
</country>
<region>
<li>Communauté de Madrid</li>
</region>
<settlement>
<li>Madrid</li>
</settlement>
</list>
<tree>
<country name="Espagne">
<region name="Communauté de Madrid">
<name sortKey="Dediego, Marta L" sort="Dediego, Marta L" uniqKey="Dediego M" first="Marta L." last="Dediego">Marta L. Dediego</name>
</region>
<name sortKey="Casta O Rodriguez, Carlos" sort="Casta O Rodriguez, Carlos" uniqKey="Casta O Rodriguez C" first="Carlos" last="Casta O-Rodriguez">Carlos Casta O-Rodriguez</name>
<name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<name sortKey="Fernandez Delgado, Raul" sort="Fernandez Delgado, Raul" uniqKey="Fernandez Delgado R" first="Raul" last="Fernandez-Delgado">Raul Fernandez-Delgado</name>
<name sortKey="Jimenez Guarde O, Jose M" sort="Jimenez Guarde O, Jose M" uniqKey="Jimenez Guarde O J" first="Jose M." last="Jimenez-Guarde O">Jose M. Jimenez-Guarde O</name>
<name sortKey="Nieto Torres, Jose L" sort="Nieto Torres, Jose L" uniqKey="Nieto Torres J" first="Jose L." last="Nieto-Torres">Jose L. Nieto-Torres</name>
<name sortKey="Regla Nava, Jose A" sort="Regla Nava, Jose A" uniqKey="Regla Nava J" first="Jose A." last="Regla-Nava">Jose A. Regla-Nava</name>
<name sortKey="Usera, Fernando" sort="Usera, Fernando" uniqKey="Usera F" first="Fernando" last="Usera">Fernando Usera</name>
</country>
</tree>
</affiliations>
</record>

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